Article
Elimination of unaltered DNA in mixed clinical samples via nuclease-assisted minor-allele enrichment.
Nucleic acids research - 2 Nov 2016
Song Chen, Liu Yibin, Fontana Rachel, Makrigiorgos Alexander, Mamon Harvey, Kulke Matthew H, Makrigiorgos G Mike
Abstract excerpt
Presence of excess unaltered, wild-type (WT) DNA providing no information of biological or clinical value often masks rare alterations containing diagnostic or therapeutic clues in cancer, prenatal diagnosis, infectious diseases or organ transplantation. With the surge of high-throughput technologies there is a growing demand for removing unaltered DNA over large pools-of-sequences. Here we present...
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