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Article

Pyrimidine-Dependent UV-Mediated Cross-Linking Magnifies Minor Genetic or Epigenetic Changes in Clinical Samples.

Clinical chemistry - 3 Sept 2024

Yu Fangyan, Ahmed Farzana, Smilkou Stavroula, Yasmin-Karim Sayeda, Darbeheshti Farzaneh, Markou Athina, Bullock Martyn, Boukovinas Ioannis, Adalsteinsson Viktor A, Lianidou Evi, Makrigiorgos G Mike

Abstract excerpt

BACKGROUND: Detection of minor DNA allele alterations is becoming increasingly important for early detection and monitoring of cancer. We describe a new method that uses ultraviolet light to eliminate wild-type DNA alleles and enables improved detection of minor genetic or epigenetic changes. METHODS: Pyrimidine-dependent UV-based minor-allele enrichment (PD-UVME) employed oligonucleotide probes that incorporated...

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Share to DNA Methylation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39039866
DOI: 10.1093/clinchem/hvae086
PMCID: PMC11371481

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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