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Recent Developments in Mutation Enrichment and Detection Technologies.

Clinical chemistry - 6 Oct 2022

Darbeheshti Farzaneh, Yu Fangyan, Ahmed Farzana, Adalsteinsson Viktor A, Makrigiorgos G Mike

Abstract excerpt

BACKGROUND: Presence of excess unaltered, wild-type DNA (wtDNA) providing information of little clinical value may often mask low-level mutations containing important diagnostic or therapeutic clues. This is a recurring hurdle in biotechnology and medicine, including cancer, prenatal diagnosis, infectious diseases, and organ transplantation. Mutation enrichment techniques that allow reduction of unwanted DNA to...

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PMID: 35716101
DOI: 10.1093/clinchem/hvac093

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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