Article
Leveraging Allele-Specific Expression for Therapeutic Response Gene Discovery in Glioblastoma.
Cancer research - 1 Feb 2022
Sen Arko, Prager Briana C, Zhong Cuiqing, Park Donglim, Zhu Zhe, Gimple Ryan C, Wu Qiulian, Bernatchez Jean A, Beck Sungjun, Clark Alex E, Siqueira-Neto Jair L, Rich Jeremy N, McVicker Graham
Abstract excerpt
Glioblastoma is the most prevalent primary malignant brain tumor in adults and is characterized by poor prognosis and universal tumor recurrence. Effective glioblastoma treatments are lacking, in part due to somatic mutations and epigenetic reprogramming that alter gene expression and confer drug resistance. To investigate recurrently dysregulated genes in glioblastoma, we interrogated allele-specific expression...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.