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SLFN11 Negatively Regulates Noncanonical NFκB Signaling to Promote Glioblastoma Progression

11 Aug 2022

Abstract excerpt

Glioblastoma (GBM) is an aggressive and incurable brain tumor in nearly all instances, whose disease progression is driven in part by the glioma stem cell (GSC) subpopulation. Here, we explored the effects of Schlafen family member 11 (SLFN11) in the molecular, cellular, and tumor biology of GBM. CRISPR/Cas9-mediated knockout of SLFN11 inhibited GBM cell proliferation and neurosphere growth and was associated...

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PMID: 36382088
DOI: 10.1158/2767-9764.crc-22-0192

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