Article

Leveraging Allele-Specific Expression for Therapeutic Response Gene Discovery in Glioblastoma

2021-06-22

Abstract excerpt

<h4>ABSTRACT</h4> Glioblastoma is the most prevalent primary malignant brain tumor in adults and is characterized by poor prognosis and universal tumor recurrence. Effective glioblastoma treatments are lacking, in part due to somatic mutations and epigenetic reprogramming that alter gene expression and confer drug resistance. Here, we interrogated allele-specific expression (ASE) in 43 patient-derived gliobl...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 30620c13-cb30-52e4-82ca-8bc02244367a
DOI: 10.1101/2021.06.22.449493

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Leveraging Allele-Specific Expression for Therapeutic Response Gene Discovery in GlioblastomaDOI 10.1101/2021.06.22.449493Read

Leveraging Allele-Specific Expression for Therapeutic Response Gene Discovery in Glioblastoma.Semantic proximity Read

Correlation of somatic mutation and expression identifies genes important in human glioblastoma progression and survival.Semantic proximity Read

Genomic and Transcriptomic Characterization of the New Human Glioblastoma Cell Line AHOL1Semantic proximity Read

Mapping chromatin remodelling in glioblastoma identifies epigenetic regulation of key molecular pathways and novel druggable targetsSemantic proximity Read

Genomic landscape of glioblastoma without IDH somatic mutation in 42 cases: a comprehensive analysis using RNA sequencing data.Semantic proximity Read

Genome-Wide Profiling and Clinical Significance of Alternative Splicing Events in GlioblastomaSemantic proximity Read

SLFN11 Negatively Regulates Noncanonical NFκB Signaling to Promote Glioblastoma ProgressionSemantic proximity Read

Distinct Transcription Profiles of Primary and Secondary Glioblastoma SubgroupsSemantic proximity Read

Gene expression profiling reveals molecularly and clinically distinct subtypes of glioblastoma multiformeSemantic proximity Read

Gene Expression Patterns Associated with Survival in GlioblastomaSemantic proximity Read

Chromatin landscapes reveal developmentally encoded transcriptional states that define human glioblastomaSemantic proximity Read

Digital transcriptome profiling of normal and glioblastoma-derived neural stem cells identifies genes associated with patient survivalSemantic proximity Read