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Mapping chromatin remodelling in glioblastoma identifies epigenetic regulation of key molecular pathways and novel druggable targets

6 Feb 2025

Abstract excerpt

BACKGROUND: Glioblastoma is the most common and aggressive malignant brain tumour in the adult population and its prognosis is dismal. The heterogeneous nature of the tumour, to which epigenetic dysregulation significantly contributes, is among the main therapeutic challenges of the disease. RESULTS: We have leveraged SYNGN, an experimental pipeline enabling the syngeneic comparison of glioblastoma stem cells and...

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Share to Chromatin Remodeling and Cancer
Share to Epigenetics and DNA Methylation
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PMID: 39915814
DOI: 10.1186/s12915-025-02127-9

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