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Digital transcriptome profiling of normal and glioblastoma-derived neural stem cells identifies genes associated with patient survival

9 Oct 2012

Abstract excerpt

BACKGROUND: Glioblastoma multiforme, the most common type of primary brain tumor in adults, is driven by cells with neural stem (NS) cell characteristics. Using derivation methods developed for NS cells, it is possible to expand tumorigenic stem cells continuously in vitro. Although these glioblastoma-derived neural stem (GNS) cells are highly similar to normal NS cells, they harbor mutations typical of gliomas...

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PMID: 23046790
DOI: 10.1186/gm377

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