Genomic Exploration of Distinct Molecular Phenotypes Steering Temozolomide Resistance Development in Patient-Derived Glioblastoma Cells.

doi:10.3390/ijms242115678

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Article

Genomic Exploration of Distinct Molecular Phenotypes Steering Temozolomide Resistance Development in Patient-Derived Glioblastoma Cells.

International journal of molecular sciences - 27 Oct 2023

Fabro Federica, Kers Trisha V, Feller Kate J, Beerens Cecile, Ntafoulis Ioannis, Idbaih Ahmed, Verreault Maite, Connor Kate, Biswas Archita, Salvucci Manuela, Prehn Jochen H M, Byrne Annette T, O'Farrell Alice C, Lambrechts Diether, Dilcan Gonca, Lodi Francesca, Arijs Ingrid, Kremer Andreas, Tching Chi Yen Romain, Chien Miao-Ping, Lamfers Martine L M, Leenstra Sieger

Abstract excerpt

Chemotherapy using temozolomide is the standard treatment for patients with glioblastoma. Despite treatment, prognosis is still poor largely due to the emergence of temozolomide resistance. This resistance is closely linked to the widely recognized inter- and intra-tumoral heterogeneity in glioblastoma, although the underlying mechanisms are not yet fully understood. To induce temozolomide resistance, we...

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Identifiers

PMID: 37958662
DOI: 10.3390/ijms242115678
PMCID: PMC10647455

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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