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Article

A novel locus of resistance to severe malaria in a region of ancient balancing selection.

Nature - 8 Oct 2015

Band Gavin, Rockett Kirk A, Spencer Chris C A, Kwiatkowski Dominic P

Abstract excerpt

The high prevalence of sickle haemoglobin in Africa shows that malaria has been a major force for human evolutionary selection, but surprisingly few other polymorphisms have been proven to confer resistance to malaria in large epidemiological studies. To address this problem, we conducted a multi-centre genome-wide association study (GWAS) of life-threatening Plasmodium falciparum infection (severe malaria) in...

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Identifiers

PMID: 26416757
DOI: 10.1038/nature15390
PMCID: PMC4629224

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