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Article

Human genetic variations conferring resistance to malaria.

Journal of translational medicine - 24 Sept 2025

Zhang Xiaokun, Wu Jie, Peng Yunxing, Luo Lan, Zhang Lu, Huang Xi, Chen Guoying, Li Yirong, Yi Haoan

Abstract excerpt

Malaria remains one of the most significant public health challenges globally, particularly in tropical and subtropical regions. Throughout evolutionary history, malaria-induced natural selection has profoundly influenced human genetic evolution, leading to the emergence of numerous genetic variations that confer resistance to the disease. These adaptations highlight the complicated interplay between pathogens...

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Identifiers

PMID: 40993672
DOI: 10.1186/s12967-025-07017-w
PMCID: PMC12462182

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