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Article

Gated access to the pore of a P2X receptor: structural implications for closed-open transitions.

The Journal of biological chemistry - 26 Mar 2010

Kracun Sebastian, Chaptal Vincent, Abramson Jeff, Khakh Baljit S

Abstract excerpt

P2X receptors are ligand-gated cation channels that transition from closed to open states upon binding ATP. The crystal structure of the closed zebrafish P2X4.1 receptor directly reveals that the ion-conducting pathway is formed by three transmembrane domain 2 (TM2) alpha-helices, each being prov...

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Identifiers

PMID: 20093367
DOI: 10.1074/jbc.M109.089185
PMCID: PMC2843173

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20093367-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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