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Article

Salt bridge switching from Arg290/Glu167 to Arg290/ATP promotes the closed-to-open transition of the P2X2 receptor.

Molecular pharmacology - 1 Jan 2013

Hausmann Ralf, Günther Janka, Kless Achim, Kuhlmann Daniel, Kassack Matthias U, Bahrenberg Gregor, Markwardt Fritz, Schmalzing Günther

Abstract excerpt

P2X receptors are trimeric adenosine-5'-triphosphate (ATP)-gated cation channels involved in fast signal transduction in many cell types. In this study, we used homology modeling of the rat P2X2 receptor with the zebrafish P2X4 X-ray template to determine that the side chains of the Glu167 and Arg290 residues are in close spatial vicinity within the ATP-binding pocket when the rat P2X2 channel is closed. Through...

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Identifiers

PMID: 23041661
DOI: 10.1124/mol.112.081489

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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