Article
Molecular Structure and Regulation of P2X Receptors With a Special Emphasis on the Role of P2X2 in the Auditory System.
Journal of cellular physiology - 1 Aug 2016
Mittal Rahul, Chan Brandon, Grati M'hamed, Mittal Jeenu, Patel Kunal, Debs Luca H, Patel Amit P, Yan Denise, Chapagain Prem, Liu Xue Zhong
Abstract excerpt
The P2X purinergic receptors are cation-selective channels gated by extracellular adenosine 5'-triphosphate (ATP). These purinergic receptors are found in virtually all mammalian cell types and facilitate a number of important physiological processes. Within the past few years, the characterization of crystal structures of the zebrafish P2X4 receptor in its closed and open states has provided critical insights...
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