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Article

High potency zinc modulation of human P2X2 receptors and low potency zinc modulation of rat P2X2 receptors share a common molecular mechanism.

The Journal of biological chemistry - 22 Jun 2012

Punthambaker Sukanya, Blum Jacob A, Hume Richard I

Abstract excerpt

Human P2X2 receptors (hP2X2) are strongly inhibited by zinc over the range of 2-100 μM, whereas rat P2X2 receptors (rP2X2) are strongly potentiated over the same range, and then inhibited by zinc over 100 μM. However, the biological role of zinc modulation is unknown in either species. To identify candidate regions controlling zinc inhibition in hP2X2 a homology model based on the crystal structure of zebrafish...

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Identifiers

PMID: 22556417
DOI: 10.1074/jbc.M112.369157
PMCID: PMC3381168

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