Article
A hydrophobic residue in position 15 of the rP2X3 receptor slows desensitization and reveals properties beneficial for pharmacological analysis and high-throughput screening.
Neuropharmacology - 1 Apr 2014
Hausmann Ralf, Bahrenberg Gregor, Kuhlmann Daniel, Schumacher Michaela, Braam Ursula, Bieler Dagmar, Schlusche Ilka, Schmalzing Günther
Abstract excerpt
The homotrimeric P2X3 subtype, one of the seven members of the ATP-gated P2X receptor family, plays a role in sensory neurotransmission, including nociception. To overcome the bias resulting from fast desensitization of the P2X3 receptor in dose-response analyses, a non-desensitizing P2X2-X3 receptor chimera has been repeatedly used as a surrogate for the P2X3 receptor for functional analysis. Here, we show that...
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