Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Single-molecule mitochondrial DNA sequencing shows no evidence of CpG methylation in human cells and tissues.

Nucleic acids research - 16 Dec 2021

Bicci Iacopo, Calabrese Claudia, Golder Zoe J, Gomez-Duran Aurora, Chinnery Patrick F

Abstract excerpt

Methylation on CpG residues is one of the most important epigenetic modifications of nuclear DNA, regulating gene expression. Methylation of mitochondrial DNA (mtDNA) has been studied using whole genome bisulfite sequencing (WGBS), but recent evidence has uncovered technical issues which introduce a potential bias during methylation quantification. Here, we validate the technical concerns of WGBS, and develop and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line
Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CpG Islands

Share to DNA Methylation

Share to DNA, Mitochondrial

Share to Genetic Variation

Share to Nanopore Sequencing

Share to Whole Genome Sequencing

Source

Open in PubMed Open full text

Identifiers

PMID: 34850165
DOI: 10.1093/nar/gkab1179
PMCID: PMC8682748

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Single-molecule mitochondrial DNA sequencing shows no evidence of CpG methylation in human cells and tissues.PMID 34850165Read ↗

Oxford Nanopore sequencing-based protocol to detect CpG methylation in human mitochondrial DNASemantic proximity Read ↗

Analysis of mitochondrial genome methylation using Nanopore single-molecule sequencingSemantic proximity Read ↗

Ultra-deep whole genome bisulfite sequencing reveals a single methylation hotspot in human brain mitochondrial DNASemantic proximity Read ↗

Nanopore Single-Molecule Sequencing for Mitochondrial DNA Methylation Analysis: Investigating Parkin-Associated Parkinsonism as a Proof of ConceptSemantic proximity Read ↗

CpG methylation patterns of human mitochondrial DNASemantic proximity Read ↗

Accurate and comprehensive analysis of single nucleotide variants and large deletions of the human mitochondrial genome in DNA and single cells.Semantic proximity Read ↗

Comparing methylation levels assayed in GC-rich regions with current and emerging methodsSemantic proximity Read ↗

DNA methylation calling tools for Oxford Nanopore sequencing: a survey and human epigenome-wide evaluationSemantic proximity Read ↗

Whole human genome 5’-mC methylation analysis using long read nanopore sequencingSemantic proximity Read ↗

mtDNApipe: A Pioneering Pipeline for High-Sensitivity Detection of Low-Frequency Mitochondrial DNA Mutations.Semantic proximity Read ↗

An allele-resolved nanopore-guided tour of the human placental methylomeSemantic proximity Read ↗

Long-read MitoScope reveals tissue-resolved somatic mitochondrial variation and landscape of nuclear-embedded mitochondrial sequencesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.