Article

Ultra-deep whole genome bisulfite sequencing reveals a single methylation hotspot in human brain mitochondrial DNA

2021-03-31

Abstract excerpt

<h4>ABSTRACT</h4> While DNA methylation is established as a major regulator of gene expression in the nucleus, the existence of mitochondrial DNA (mtDNA) methylation remains controversial. Here, we characterised the mtDNA methylation landscape in the prefrontal cortex of neurological healthy individuals (n=26) and patients with Parkinson’s disease (n=27), using a combination of whole genome bisulfite sequencing (...

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Literature Corpus work: bae13236-740a-5a98-a0ec-aa0733150725
DOI: 10.1101/2021.03.30.437685

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