Article
mtDNApipe: A Pioneering Pipeline for High-Sensitivity Detection of Low-Frequency Mitochondrial DNA Mutations.
Analytical chemistry - 27 Jan 2026
Guo Wenjie, Li Shengjing, Sun Tianlei, Lei Zhangwen, Zhou Kaixiang, Zhang Lei, Guo Xu, Zhou Feng, Liu Yang, Xing Jinliang
Abstract excerpt
Accurate detection of low-frequency mitochondrial DNA (mtDNA) mutations is essential for advancing molecular profiling, yet it is often confounded by sequencing artifacts, nuclear mitochondrial DNA (NUMTs), and oxidative damage-induced errors. Although unique molecular identifier (UMI)-based duplex sequencing can reduce such errors, its high cost and limited efficiency restrict its widespread use. Here, we...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.