Article

Analysis of mitochondrial genome methylation using Nanopore single-molecule sequencing

2021-02-06

Abstract excerpt

The level and the biological significance of mitochondrial DNA (mtDNA) methylation in human cells is a controversial topic. Using long-read third-generation sequencing technology, mtDNA methylation can be detected directly from the sequencing data, which overcomes previously suggested biases, introduced by bisulfite treatment-dependent methods. We investigated mtDNA from whole blood-derived DNA and established a w...

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Literature Corpus work: 4c07d7e1-0a93-5e7a-948b-e8183c871627
DOI: 10.1101/2021.02.05.429923

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