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CpG methylation patterns of human mitochondrial DNA

21 Mar 2016

Abstract excerpt

The epigenetic modification of mitochondrial DNA (mtDNA) is still in controversy. To clarify this point, we applied the gold standard method for DNA methylation, bisulfite pyrosequencing, to examine human mtDNA methylation status. Before bisulfite conversion, BamHI was used to digest DNA to open the loop of mtDNA. The results demonstrated that the linear mtDNA had significantly higher bisulfite conversion...

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PMID: 26996456
DOI: 10.1038/srep23421

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