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Nanopore Single-Molecule Sequencing for Mitochondrial DNA Methylation Analysis: Investigating Parkin-Associated Parkinsonism as a Proof of Concept

28 Sept 2021

Abstract excerpt

Objective:To establish a workflow for mitochondrial DNA (mtDNA) CpG methylation using Nanopore whole-genome sequencing and perform first pilot experiments on affectedParkinbiallelic mutation carriers (Parkin-PD) and healthy controls. Background:Mitochondria, including mtDNA, are established key players in Parkinson's disease (PD) pathogenesis. Mutations in Parkin, essential for degradation of damaged...

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PMID: 34650424
DOI: 10.3389/fnagi.2021.713084

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