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Article

Association of prostate cancer risk variants with gene expression in normal and tumor tissue.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jan 2015

Penney Kathryn L, Sinnott Jennifer A, Tyekucheva Svitlana, Gerke Travis, Shui Irene M, Kraft Peter, Sesso Howard D, Freedman Matthew L, Loda Massimo, Mucci Lorelei A, Stampfer Meir J

Abstract excerpt

BACKGROUND: Numerous germline genetic variants are associated with prostate cancer risk, but their biologic role is not well understood. One possibility is that these variants influence gene expression in prostate tissue. We therefore examined the association of prostate cancer risk variants with the expression of genes nearby and genome-wide. METHODS: We generated mRNA expression data for 20,254 genes with the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25371445
DOI: 10.1158/1055-9965.EPI-14-0694-T
PMCID: PMC4294966

Genes

IMPACT
ITGA6
KLHL33
MLPH
MSMB
NEFM
NUDT11
PSCA
RBPMS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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