Article
Risk SNP-Mediated Promoter-Enhancer Switching Drives Prostate Cancer through lncRNA PCAT19.
Cell - 26 Jul 2018
Hua Junjie Tony, Ahmed Musaddeque, Guo Haiyang, Zhang Yuzhe, Chen Sujun, Soares Fraser, Lu Jennifer, Zhou Stanley, Wang Miranda, Li Hui, Larson Nicholas B, McDonnell Shannon K, Patel Parasvi S, Liang Yi, Yao Cindy Q, van der Kwast Theodorus, Lupien Mathieu, Feng Felix Y, Zoubeidi Amina, Tsao Ming-Sound, Thibodeau Stephen N, Boutros Paul C, He Housheng Hansen
Abstract excerpt
The prostate cancer (PCa) risk-associated SNP rs11672691 is positively associated with aggressive disease at diagnosis. We showed that rs11672691 maps to the promoter of a short isoform of long noncoding RNA PCAT19 (PCAT19-short), which is in the third intron of the long isoform (PCAT19-long). The risk variant is associated with decreased and increased levels of PCAT19-short and PCAT19-long, respectively....
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