Modulation of long noncoding RNAs by risk SNPs underlying genetic predispositions to prostate cancer.

doi:10.1038/ng.3637

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Modulation of long noncoding RNAs by risk SNPs underlying genetic predispositions to prostate cancer.

Nature genetics - 1 Oct 2016

Guo Haiyang, Ahmed Musaddeque, Zhang Fan, Yao Cindy Q, Li SiDe, Liang Yi, Hua Junjie, Soares Fraser, Sun Yifei, Langstein Jens, Li Yuchen, Poon Christine, Bailey Swneke D, Desai Kinjal, Fei Teng, Li Qiyuan, Sendorek Dorota H, Fraser Michael, Prensner John R, Pugh Trevor J, Pomerantz Mark, Bristow Robert G, Lupien Mathieu, Feng Felix Y, Boutros Paul C, Freedman Matthew L, Walsh Martin J, He Housheng Hansen

Abstract excerpt

Long noncoding RNAs (lncRNAs) represent an attractive class of candidates to mediate cancer risk. Through integrative analysis of the lncRNA transcriptome with genomic data and SNP data from prostate cancer genome-wide association studies (GWAS), we identified 45 candidate lncRNAs associated with risk to prostate cancer. We further evaluated the mechanism underlying the top hit, PCAT1, and found that a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromatin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enhancer Elements, Genetic

Share to Gene Expression Regulation, Neoplastic

Share to Mice, Inbred NOD

Share to Prostatic Neoplasms

Share to Receptors, Androgen

Share to RNA, Long Noncoding

Share to Xenograft Model Antitumor Assays

Source

Open in PubMed

Identifiers

PMID: 27526323
DOI: 10.1038/ng.3637

Genes

DHCR24
GNMT
ONECUT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Modulation of long noncoding RNAs by risk SNPs underlying genetic predispositions to prostate cancer.PMID 27526323Read ↗

Long Non-Coding RNAs at the Chromosomal Risk Loci Identified by Prostate and Breast Cancer GWAS.Semantic proximity Read ↗

Risk SNP-Mediated Promoter-Enhancer Switching Drives Prostate Cancer through lncRNA PCAT19.Semantic proximity Read ↗

Mechanistic insights into genetic susceptibility to prostate cancer.Semantic proximity Read ↗

Prostate cancer: Risk SNPs modulate lncRNAs.Semantic proximity Read ↗

Human polymorphisms at long non-coding RNAs (lncRNAs) and association with prostate cancer risk.Semantic proximity Read ↗

Current Insights into Long Non-Coding RNAs (LncRNAs) in Prostate CancerSemantic proximity Read ↗

Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study.Semantic proximity Read ↗

Genetic susceptibility to prostate cancer in Taiwan: A genome-wide association study.Semantic proximity Read ↗

PCAT1: An oncogenic lncRNA in diverse cancers and a putative therapeutic target.Semantic proximity Read ↗

Comprehensive functional annotation of 77 prostate cancer risk loci.Semantic proximity Read ↗

Identification of candidate genes for prostate cancer-risk SNPs utilizing a normal prostate tissue eQTL data set.Semantic proximity Read ↗

Prostate cancer-associated lncRNAs.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.