Article
Common genetic variants in the PSCA gene influence gene expression and bladder cancer risk.
Proceedings of the National Academy of Sciences of the United States of America - 27 Mar 2012
Fu Yi-Ping, Kohaar Indu, Rothman Nathaniel, Earl Julie, Figueroa Jonine D, Ye Yuanqing, Malats Núria, Tang Wei, Liu Luyang, Garcia-Closas Montserrat, Muchmore Brian, Chatterjee Nilanjan, Tarway McAnthony, Kogevinas Manolis, Porter-Gill Patricia, Baris Dalsu, Mumy Adam, Albanes Demetrius, Purdue Mark P, Hutchinson Amy, Carrato Alfredo, Tardón Adonina, Serra Consol, García-Closas Reina, Lloreta Josep, Johnson Alison, Schwenn Molly, Karagas Margaret R, Schned Alan, Diver W Ryan, Gapstur Susan M, Thun Michael J, Virtamo Jarmo, Chanock Stephen J, Fraumeni Joseph F, Silverman Debra T, Wu Xifeng, Real Francisco X, Prokunina-Olsson Ludmila
Abstract excerpt
Genome-wide association studies have identified a SNP, rs2294008, on 8q24.3 within the prostate stem cell antigen (PSCA) gene, as a risk factor for bladder cancer. To fine-map this region, we imputed 642 SNPs within 100 Kb of rs2294008 in addition to 33 markers genotyped in one of the reported genome-wide association study in 8,652 subjects. A multivariable logistic regression model adjusted for rs2294008...