Article
Large-scale association analysis in Asians identifies new susceptibility loci for prostate cancer.
Nature communications - 7 Oct 2015
Wang Meilin, Takahashi Atsushi, Liu Fang, Ye Dingwei, Ding Qiang, Qin Chao, Yin Changjun, Zhang Zhengdong, Matsuda Koichi, Kubo Michiaki, Na Rong, Lin Xiaoling, Jiang Haowen, Ren Shancheng, Sun Jielin, Zheng S Lilly, Marchand Loic Le, Isaacs William B, Mo Zengnan, Haiman Christopher A, Sun Yinghao, Nakagawa Hidewaki, Xu Jianfeng
Abstract excerpt
Genome-wide association studies (GWAS) have identified ∼100 genetic loci associated with prostate cancer risk. Less than a dozen of these loci were initially identified from GWAS in two Asian populations, likely because of smaller sample sizes of these individual GWAS in Asians. Here, we conduct a large-scale meta-analysis of two GWAS from the Japanese population (1,583 cases and 3,386 controls) and the Chinese...
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