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Article

Identification of Candidate mRNA Isoforms for Prostate Cancer-Risk SNPs Utilizing Iso-eQTL and sQTL Methods.

International journal of molecular sciences - 17 Oct 2022

Moradi Afshin, Sharma Harsh, Sharma Ravi Datta, Fernando Achala, Barrero Roberto A, Batra Jyotsna

Abstract excerpt

Single nucleotide polymorphisms (SNPs) impacting the alternative splicing (AS) process (sQTLs) or isoform expression (iso-eQTL) are implicated as important cancer regulatory elements. To find the sQTL and iso-eQTL, we retrieved prostate cancer (PrCa) tissue RNA-seq and genotype data originating from 385 PrCa European patients from The Cancer Genome Atlas. We conducted RNA-seq analysis with isoform-based and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36293264
DOI: 10.3390/ijms232012406
PMCID: PMC9604153

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