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Glioma Cells Acquire Stem-like Characters by Extrinsic Ribosome Stimuli

1 Nov 2021

Abstract excerpt

Although glioblastoma (GBM) stem-like cells (GSCs), which retain chemo-radio resistance and recurrence, are key prognostic factors in GBM patients, the molecular mechanisms of GSC development are largely unknown. Recently, several studies revealed that extrinsic ribosome incorporation into somatic cells resulted in stem cell properties and served as a key trigger and factor for the cell reprogramming process. In...

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PMID: 34831193
DOI: 10.3390/cells10112970

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