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SMYD2 induced PGC1α methylation promotes stemness maintenance of glioblastoma stem cells

9 May 2024

Abstract excerpt

BACKGROUND: The high fatality rate of glioblastoma (GBM) is attributed to glioblastoma stem cells (GSCs), which exhibit heterogeneity and therapeutic resistance. Metabolic plasticity of mitochondria is the hallmark of GSCs. Targeting mitochondrial biogenesis of GSCs is crucial for improving clinical prognosis in GBM patients. METHODS: SMYD2-induced PGC1α methylation and followed nuclear export are confirmed by...

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Share to Cancer, Hypoxia, and Metabolism
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PMID: 38721826
DOI: 10.1093/neuonc/noae090

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