Article

GRP78 promotes stemness in normal and neoplastic cells

2019-07-31

Abstract excerpt

<h4>ABSTRACT</h4> Reliable approaches to identify stem cell mechanisms that mediate aggressive cancer could have great therapeutic value, based on the growing evidence of embryonic signatures in metastatic cancers. However, how to best identify and target stem-like mechanisms aberrantly acquired by cancer cells has been challenging. We harnessed the power of reprogramming to examine GRP78, a chaperone protein gen...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ff25c1db-d99f-5cc1-ab35-f58a671571f9
DOI: 10.1101/720698

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

GRP78 promotes stemness in normal and neoplastic cellsDOI 10.1101/720698Read

CRIPTO/GRP78 signaling maintains fetal and adult mammary stem cells ex vivo.Semantic proximity Read

Role of the Unfolded Protein Response Regulator GRP78/BiP in Development, Cancer, and Neurological DisordersSemantic proximity Read

Grp78 as a therapeutic target for refractory head-neck cancer with CD24(-)CD44(+) stemness phenotype.Semantic proximity Read

The unfolded protein response as regulator of cancer stemness and differentiation: Mechanisms and implications for cancer therapySemantic proximity Read

Cell surface GRP78 signaling: An emerging role as a transcriptional modulator in cancerSemantic proximity Read

Progesterone receptors drive advanced breast cancer phenotypes including circulating tumor-and stem-like cell expansion in the context of <i>ESR1</i> mutationSemantic proximity Read

p97/VCP is highly expressed in the stem-like cells of breast cancer and controls cancer stemness partly through the unfolded protein responseSemantic proximity Read

Human iPSC-based breast cancer model identifies S100P-dependent cancer stemness induced by BRCA1 mutation.Semantic proximity Read

ΔNp63/p73 drive metastatic colonization by controlling a regenerative epithelial stem cell program in quasi-mesenchymal cancer stem cellsSemantic proximity Read

An Intricate Connection between Alternative Splicing and Phenotypic Plasticity in Development and Cancer.Semantic proximity Read

New insights into the unfolded protein response in stem cellsSemantic proximity Read

SGCE Promotes Breast Cancer Stem Cells by Stabilizing EGFRSemantic proximity Read