Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

UPF1/circRPPH1/ATF3 feedback loop promotes the malignant phenotype and stemness of GSCs.

Cell death & disease - 23 Jul 2022

Xu Jinkun, Zhang Guoqing, Hu Jinpeng, Li Hao, Zhao Junshuang, Zong Shengliang, Guo Zhengting, Jiang Yang, Jing Zhitao

Abstract excerpt

Glioblastoma multiforme (GBM) is the most lethal type of craniocerebral gliomas. Glioma stem cells (GSCs) are fundamental reasons for the malignancy and recurrence of GBM. Revealing the critical mechanism within GSCs' self-renewal ability is essential. Our study found a novel circular RNA (circRPPH1) that was up-regulated in GSCs and correlated with poor survival. The effect of circRPPH1 on the malignant...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinogenesis
Share to Feedback
Share to Glioblastoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glioma

Share to Neoplastic Stem Cells

Share to Nestin

Share to RNA Helicases

Share to Transforming Growth Factor beta

Source

Open in PubMed Open full text

Identifiers

PMID: 35871061
DOI: 10.1038/s41419-022-05102-2
PMCID: PMC9308777

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

UPF1/circRPPH1/ATF3 feedback loop promotes the malignant phenotype and stemness of GSCs.PMID 35871061Read ↗

The SRSF1/circATP5B/miR-185-5p/HOXB5 Feedback Loop Regulates the Proliferation of Glioma Stem Cells via the IL6-mediated JAK2/STAT3 Signaling PathwaySemantic proximity Read ↗

CREB5 promotes the proliferation and self-renewal ability of glioma stem cellsSemantic proximity Read ↗

Identification of PDLIM1 as a glioblastoma stem cell marker driving tumorigenesis and chemoresistanceSemantic proximity Read ↗

Circular RNA - circCLIP2 is predominantly expressed in GSC niche and enhances glioblastoma aggressiveness via EMT and ECM signalingSemantic proximity Read ↗

Redox-Regulated Pathways in Glioblastoma Stem-like Cells: Mechanistic Insights and Therapeutic ImplicationsSemantic proximity Read ↗

IGF2BP3 binding circGNB1 promotes the malignant phenotype of GSCs via miR-515-5p/miR-582-3p mediated XPR1 expression changeSemantic proximity Read ↗

Plasmatic circRNA Predicting the Occurrence of Human GlioblastomaSemantic proximity Read ↗

CircLMF1 Activates the TFE3-MVP/ABCC1 Pathway to Promote Mesenchymal Transition and Sensitize Glioblastoma to FerroptosisSemantic proximity Read ↗

Differential Expression of Circular RNAs in Glioblastoma Multiforme and Its Correlation with PrognosisSemantic proximity Read ↗

A Novel Role of BIRC3 in Stemness Reprogramming of GlioblastomaSemantic proximity Read ↗

CircRNF10 triggers a positive feedback loop to facilitate progression of glioblastoma via redeploying the ferroptosis defense in GSCsSemantic proximity Read ↗

CircVPS8 promotes the malignant phenotype and inhibits ferroptosis of glioma stem cells by acting as a scaffold for MKRN1, SOX15 and HNF4A.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.