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Polyploid giant cancer cells and tumor budding: translation from basic research to clinical application

16 Jul 2025

Abstract excerpt

Polyploid giant cancer cells (PGCCs) represent a distinct subpopulation of tumor cells characterized by enlarged or multiple nuclei and aneuploidy. PGCCs are products of genomic instability, possessing cancer stem cell properties and exhibiting significant resistance to radiotherapy and chemotherapy. They can generate highly invasive daughter cells through asymmetric division, exhibiting epithelial-mesenchymal...

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PMID: 40740858
DOI: 10.3389/fonc.2025.1611920

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