Article
A high-resolution HLA reference panel capturing global population diversity enables multi-ancestry fine-mapping in HIV host response.
Nature genetics - 1 Oct 2021
Luo Yang, Kanai Masahiro, Choi Wanson, Li Xinyi, Sakaue Saori, Yamamoto Kenichi, Ogawa Kotaro, Gutierrez-Arcelus Maria, Gregersen Peter K, Stuart Philip E, Elder James T, Forer Lukas, Schönherr Sebastian, Fuchsberger Christian, Smith Albert V, Fellay Jacques, Carrington Mary, Haas David W, Guo Xiuqing, Palmer Nicholette D, Chen Yii-Der Ida, Rotter Jerome I, Taylor Kent D, Rich Stephen S, Correa Adolfo, Wilson James G, Kathiresan Sekar, Cho Michael H, Metspalu Andres, Esko Tonu, Okada Yukinori, Han Buhm, McLaren Paul J, Raychaudhuri Soumya
Abstract excerpt
Fine-mapping to plausible causal variation may be more effective in multi-ancestry cohorts, particularly in the MHC, which has population-specific structure. To enable such studies, we constructed a large (n = 21,546) HLA reference panel spanning five global populations based on whole-genome sequences. Despite population-specific long-range haplotypes, we demonstrated accurate imputation at G-group resolution...
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