Histological and immunohistochemical features and genetic alterations in the malignant progression of giant cell tumor of bone: a possible association with TP53 mutation and loss of H3K27 trimethylation.

doi:10.1038/s41379-021-00972-x

Article

Histological and immunohistochemical features and genetic alterations in the malignant progression of giant cell tumor of bone: a possible association with TP53 mutation and loss of H3K27 trimethylation.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 May 2022

Ishihara Shin, Yamamoto Hidetaka, Iwasaki Takeshi, Toda Yu, Yamamoto Takeo, Yoshimoto Masato, Ito Yoshihiro, Susuki Yousuke, Kawaguchi Kengo, Kinoshita Izumi, Yamada Yuichi, Kohashi Kenichi, Fujiwara Toshifumi, Setsu Nokitaka, Endo Makoto, Matsumoto Yoshihiro, Kakuda Yuko, Nakashima Yasuharu, Oda Yoshinao

Abstract excerpt

In rare cases, giant cell tumor of bone (GCTB) can undergo primary or secondary malignant transformation to malignant giant cell tumor of bone (MGCTB), but the details of the molecular alterations are still unclear. The present study aimed to elucidate the clinicopathologic and molecular features of MGCTBs based on immunohistochemistry, fluorescence in situ hybridization (FISH) and next generation sequencing...

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Histological and immunohistochemical features and genetic alterations in the malignant progression of giant cell tumor of bone: a possible association with TP53 mutation and loss of H3K27 trimethylation.

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