Article
Histone 3.3 mutations in giant cell tumor and giant cell-rich sarcomas of bone.
Human pathology - 1 Oct 2017
Righi Alberto, Mancini Irene, Gambarotti Marco, Picci Piero, Gamberi Gabriella, Marraccini Cristina, Dei Tos Angelo Paolo, Simi Lisa, Pinzani Pamela, Franchi Alessandro
Abstract excerpt
Mutually exclusive histone 3.3 gene mutations have been recognized in chondroblastoma and giant cell tumor of bone (GCTB), which may be useful for differential diagnostic purposes in morphologically ambiguous cases. Although more than 90% of GCTBs present histone 3.3 variants exclusively in the H3F3A gene, chondroblastoma is mutated mainly in H3F3B. In this study, we examined a series of giant cell-rich primary...
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