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Article

Diagnostic Utility of Genetic and Immunohistochemical H3-3A Mutation Analysis in Giant Cell Tumour of Bone.

International journal of molecular sciences - 16 Jan 2022

Wągrodzki Michał, Tysarowski Andrzej, Seliga Katarzyna, Wojnowska Aneta, Stepaniuk Maria, Castañeda Wysocka Patrycja, Makuła Donata, Pieńkowski Andrzej, Szostakowski Bartłomiej, Zub Renata, Rutkowski Piotr

Abstract excerpt

To validate the reliability and implementation of an objective diagnostic method for giant cell tumour of bone (GCTB). H3-3A gene mutation testing was performed using two different methods, Sanger sequencing and immunohistochemical (IHC) assays. A total of 214 patients, including 120 with GCTB and 94 with other giant cell-rich bone lesions, participated in the study. Sanger sequencing and IHC with anti-histone...

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Identifiers

PMID: 35055156
DOI: 10.3390/ijms23020969
PMCID: PMC8778699

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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