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Article

Phenotypic and molecular differences between giant-cell tumour of soft tissue and its bone counterpart.

Histopathology - 1 Sept 2017

Mancini Irene, Righi Alberto, Gambarotti Marco, Picci Piero, Dei Tos Angelo P, Billings Steven D, Simi Lisa, Franchi Alessandro

Abstract excerpt

AIMS: Giant-cell tumour (GCT) of soft tissue (GCT-ST) is a primary soft tissue neoplasm that is histologically similar to GCT of bone (GCT-B). Recently, it has been reported that >90% of GCT-Bs have a driver mutation in the H3F3A gene. As the relationship between GCT-ST and GCT-B is unclear, the aim of this study was to compare a series of GCT-STs and GCT-Bs with regard to the presence of H3F3A mutations and...

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Source

Identifiers

PMID: 28477388
DOI: 10.1111/his.13249

Genes

RUNX2
SATB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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