Article
Anti-Histone H3.3 G34W antibody is a sensitive and highly specific immunohistochemistry marker for the diagnosis of Giant cell tumor of bone. A validation based on analysis of 198 cases from a single centre in India.
Indian journal of pathology & microbiology - 1 Jan 2000
Kamble Anvesh, Hui Monalisa, Rao K Nageshwara, Narayanan Ramakrishna, Reddy B Rajeev, Uppin Shantveer G, Chandrasekhar Patnala
Abstract excerpt
Context: The diagnosis of giant cell tumor of bone (GCTB) is difficult in small biopsies with unusual age of presentation, location, and extensive secondary changes. Most of the GCTBs harbor H3F3A G34W mutations with a subset of cases showing alternate G34V, G34R, and G34L mutations. Objectives: To analyze the expression of anti-histone H3.3G34W antibody in different cellular components of GCTB across different...
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