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Histone H3.3 mutation in giant cell tumor of bone: an update in pathology.

Medical molecular morphology - 1 Mar 2020

Yamamoto Hidetaka, Ishihara Shin, Toda Yu, Oda Yoshinao

Abstract excerpt

Giant cell tumor of bone (GCTB) is a locally aggressive bone tumor that frequently shows local recurrence and occasionally shows malignant transformation to high-grade sarcoma. Histologically, conventional GCTB is composed mainly of three types of cells: mononuclear neoplastic cells with an osteoblastic precursor phenotype, mononuclear histiocytic cells, and osteoclast-like multinucleated giant cells. These cells...

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PMID: 31748824
DOI: 10.1007/s00795-019-00238-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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