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H3F3A (Histone 3.3) G34W Immunohistochemistry: A Reliable Marker Defining Benign and Malignant Giant Cell Tumor of Bone.

The American journal of surgical pathology - 1 Aug 2017

Amary Fernanda, Berisha Fitim, Ye Hongtao, Gupta Manu, Gutteridge Alice, Baumhoer Daniel, Gibbons Rebecca, Tirabosco Roberto, O'Donnell Paul, Flanagan Adrienne M

Abstract excerpt

Giant cell tumor of bone (GCTB) is a locally aggressive subarticular tumor. Having recently reported that H3.3 G34W mutations are characteristic of this tumor type, we have now investigated the sensitivity and specificity of the anti-histone H3.3 G34W rabbit monoclonal antibody in a wide variety of tumors including histologic mimics of GCTB to assess its value as a diagnostic marker. We also determined the...

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Adolescent
Biomarkers, Tumor
Bone Neoplasms
Histones
Immunohistochemistry

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PMID: 28505000
DOI: 10.1097/PAS.0000000000000859
PMCID: PMC5510691

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