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Article

Giant cell tumor of bone: updated molecular pathogenesis and tumor biology.

Human pathology - 1 Nov 2018

Noh Byeong-Joo, Park Yong-Koo

Abstract excerpt

Giant cell tumor of bone (GCTB)-related clonal aberrations occur in a background of epigenetic histone modifications (especially the G34W mutation of H3F3A gene) that induce cytogenetic abnormalities. Clonal aberrations are closely linked to the aggressiveness of GCTB. The "neoplastic" mononuclear stromal cells in GCTB express fundamental RANKLs and various chemokines and cytokines associated with monocyte...

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Identifiers

PMID: 29944971
DOI: 10.1016/j.humpath.2018.06.017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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