Article
Reliability and Role of Mutation-specific H3F3A (Histone 3-3) G34W Immunohistochemistry to Differentiate Giant Cell Tumor of Bone From its Clinicoradiologic and Histologic Mimics: An Institutional Study.
Applied immunohistochemistry & molecular morphology : AIMM - 1 Jan 2022
Pasricha Sunil, Pruthi Manish, Jajodia Ankush, Kumar Ankur, Gupta Gurudutt, Sharma Anila, Tiwari Akshay, Rohela Himanshu, Durga Garima, Kamboj Meenakshi, Koyyala Venkata P B, Mehta Anurag
Abstract excerpt
Giant cell tumor of bone (GCTB) is a benign neoplasm, which can sometimes be a diagnostic challenge, especially in small biopsies, due to its histologic benign and malignant mimics. We evaluated the role of H3.3 G34W immunohistochemistry (IHC) antibody in diagnosing GCTB and its role in differentiating it from its close histologic mimics. A total of 120 cases (80 cases of GCTB and 40 cases of histologic mimics)...
Topics
- Bone Neoplasms
- Giant Cell Tumor of Bone
- Histones
- Humans
- Immunohistochemistry
- Mutation
- Reproducibility of Results