Article

Drivers underpinning the malignant transformation of giant cell tumour of bone

2020-06-16

Abstract excerpt

The rare benign giant cell tumour of bone (GCTB) is defined by an almost unique G34W oncohistone mutation in the H3.3 histone gene. Here we reveal the genomic and methylation patterns underlying the rare clinical phenomena of benign metastases and malignant transformation of GCTB.

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Literature Corpus work: 0d280fde-b955-56f4-809d-3b699a5b6d77
DOI: 10.1101/2020.06.14.20129809

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