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Article

Gene replacement strategies validate the use of functional tags on centromeric chromatin and invalidate an essential role for CENP-AK124ub.

Cell reports - 2 Nov 2021

Salinas-Luypaert Catalina, Allu Praveen Kumar, Logsdon Glennis A, Dawicki-McKenna Jennine M, Gambogi Craig W, Fachinetti Daniele, Black Ben E

Abstract excerpt

Functional tags are ubiquitous in cell biology, and for studies of one chromosomal locus, the centromere, tags have been remarkably useful. The centromere directs chromosome inheritance at cell division. The location of the centromere is defined by a histone H3 variant, CENP-A. The regulation of the chromatin assembly pathway essential for centromere inheritance and function includes posttranslational...

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Identifiers

PMID: 34731637
DOI: 10.1016/j.celrep.2021.109924
PMCID: PMC8643106

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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