Genetic screening identifies a SUMO protease dynamically maintaining centromeric chromatin.

doi:10.1038/s41467-019-14276-x

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Article

Genetic screening identifies a SUMO protease dynamically maintaining centromeric chromatin.

Nature communications - 24 Jan 2020

Mitra Sreyoshi, Bodor Dani L, David Ana F, Abdul-Zani Izma, Mata João F, Neumann Beate, Reither Sabine, Tischer Christian, Jansen Lars E T

Abstract excerpt

Centromeres are defined by a self-propagating chromatin structure based on stable inheritance of CENP-A containing nucleosomes. Here, we present a genetic screen coupled to pulse-chase labeling that allow us to identify proteins selectively involved in deposition of nascent CENP-A or in long-term transmission of chromatin-bound CENP-A. These include factors with known roles in DNA replication, repair, chromatin...

Topics

Biocatalysis
Cell Cycle
Centromere
Centromere Protein A
Chromatin
Cysteine Endopeptidases
Genetic Testing
Genotype
HeLa Cells
Humans
Kinetochores
Protein Subunits
Proteolysis
Sumoylation

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Identifiers

PMID: 31980633
DOI: 10.1038/s41467-019-14276-x
PMCID: PMC6981222

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