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Article

Synthetic physical interactions map kinetochore regulators and regions sensitive to constitutive Cdc14 localization.

Proceedings of the National Academy of Sciences of the United States of America - 18 Aug 2015

Ólafsson Guðjón, Thorpe Peter H

Abstract excerpt

The location of proteins within eukaryotic cells is often critical for their function and relocation of proteins forms the mainstay of regulatory pathways. To assess the importance of protein location to cellular homeostasis, we have developed a methodology to systematically create binary physical interactions between a query protein and most other members of the proteome. This method allows us to rapidly assess...

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Identifiers

PMID: 26240346
DOI: 10.1073/pnas.1506101112
PMCID: PMC4547228

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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