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Article

Molecular and structural basis of olfactory sensory neuron axon coalescence by Kirrel receptors.

Cell reports - 2 Nov 2021

Wang Jing, Vaddadi Neelima, Pak Joseph S, Park Yeonwoo, Quilez Sabrina, Roman Christina A, Dumontier Emilie, Thornton Joseph W, Cloutier Jean-François, Özkan Engin

Abstract excerpt

Projections from sensory neurons of olfactory systems coalesce into glomeruli in the brain. The Kirrel receptors are believed to homodimerize via their ectodomains and help separate sensory neuron axons into Kirrel2- or Kirrel3-expressing glomeruli. Here, we present the crystal structures of homodimeric Kirrel receptors and show that the closely related Kirrel2 and Kirrel3 have evolved specific sets of polar and...

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Source

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Identifiers

PMID: 34731636
DOI: 10.1016/j.celrep.2021.109940
PMCID: PMC8628261

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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