Axon guidance of mouse olfactory sensory neurons by odorant receptors and the beta2 adrenergic receptor.

doi:10.1016/j.cell.2004.05.013

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Article

Axon guidance of mouse olfactory sensory neurons by odorant receptors and the beta2 adrenergic receptor.

Cell - 11 Jun 2004

Feinstein Paul, Bozza Thomas, Rodriguez Ivan, Vassalli Anne, Mombaerts Peter

Abstract excerpt

Odorant receptors (ORs) provide the core determinant of identity for axons of olfactory sensory neurons (OSNs) to coalesce into glomeruli in the olfactory bulb. Here, using gene targeting in mice, we examine how the OR protein determines axonal identity. An OR::GFP fusion protein is present in axons, consistent with a direct function of ORs in axon guidance. When the OR coding region is deleted, we observe OSNs...

Topics

Alleles
Animals
Cell Communication
Cell Differentiation
Cilia
Gene Expression Regulation, Developmental
Gene Targeting
Green Fluorescent Proteins
Growth Cones
Luminescent Proteins
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Transgenic

Mutation

Olfactory Bulb

Olfactory Receptor Neurons

Open Reading Frames

Receptors, Adrenergic, beta-2

Receptors, Odorant

Source

Open in PubMed

Identifiers

PMID: 15186782
DOI: 10.1016/j.cell.2004.05.013

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