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Article

Kin of IRRE-like Protein 2 Is a Phosphorylated Glycoprotein That Regulates Basal Insulin Secretion.

The Journal of biological chemistry - 23 Oct 2015

Yesildag Burcak, Bock Thomas, Herrmanns Karolin, Wollscheid Bernd, Stoffel Markus

Abstract excerpt

Direct interactions among pancreatic β-cells via cell surface proteins inhibit basal and enhance stimulated insulin secretion. Here, we functionally and biochemically characterized Kirrel2, an immunoglobulin superfamily protein with β-cell-specific expression in the pancreas. Our results show that Kirrel2 is a phosphorylated glycoprotein that co-localizes and interacts with the adherens junction proteins...

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Share to Glycosylation
Share to Immunoglobulins
Share to Insulin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Insulin Secretion

Share to Islets of Langerhans

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Share to Protein Processing, Post-Translational

Share to Sequence Homology, Amino Acid

Source

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Identifiers

PMID: 26324709
DOI: 10.1074/jbc.M115.684704
PMCID: PMC4646245

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